The main road running through Fuquay-Varina is US-401, from Raleigh and Garner in the north to Lillington and Fayetteville in the south. NC-42 — linking Fuquay to the outskirts of Cary and Durham in the north, and Angier and Kinston in the east — and NC-55 — which runs through Sanford in the southwest to Wilson in the northwest — also run through town.
